Anomaly Detection in Clinical Data to Increase Drug Safety

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Anomaly Detection in Clinical Data to Increase Drug Safety

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value<p>Join me in a walkthrough of my positive journey in collaborative learning, by joining Omdena’s real-world challenges. How I went through a complete life cycle of machine learning projects in an impact cause like analyzing and detecting anomalies in cancer clinical data. And how we deployed a REST API to detect clinical data anomalies for FlaskData in this <a href="https://omdena.com/projects/ai-drug-safety/" target="_blank" rel="noopener">drug safety challenge</a>.</p>
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Join me in a walkthrough of my positive journey in collaborative learning, by joining Omdena’s real-world challenges. How I went through a complete life cycle of machine learning projects in an impact cause like analyzing and detecting anomalies in cancer clinical data. And how we deployed a REST API to detect clinical data anomalies for FlaskData in this drug safety challenge.

Execution time: 0.0011 seconds

Execution time: 0.0002 seconds

It took a year into the COVID-19 pandemic for an mRNA-based vaccine to be developed and emphasized the effect of clinical trials of drugs. This has been a powerful development in quelling the gruesome effect of the virus with millions of deaths, positive cases, and decreased herd immunity. The most important game-changer between the part of the world recovering partially & others still reeling with the pandemic has been the accessibility to vaccines. 

A clinical trial procedure

A clinical trial undergoes a lengthy procedure of tests, research, and analysis before it becomes available for use by the public. 

Phase 1 consists of testing the drug on healthy individuals checking the safety, how the body metabolizes the drug, dosage, and side effects. 

Phase 2 requires testing on larger groups of affected individuals probing the drug efficacy, feasible protocols & tolerability. 

Phase 3 involves testing on wider demographics examining the long-term effectiveness, assessing safe for public usage, adverse events, placebo & standard comparators in randomized control group trials. 

Finally, it is sent to medical regulatory bodies for approval and further testing to be rendered safe for use.

A project to increase drug safety using data science

The clinical data being generated by multiple sources are exploding in terms of variety, volume & velocity, unsynchronized from multiple sources, and unstructured in time, place, or doctor visits especially with the growing number of apps for healthcare and wearable devices. The project is indispensable in providing a much-needed independent validation of medical decisions that affect everyone, especially vaccines for a pandemic such as covid-19. While regulatory bodies and tech companies have enormous resources to sift through exploding health-related data but modus operandi on data privacy-related laws, data accessibility to the public and data-driven decisions affecting the entire world’s population are still in their nascent stages. Omdena and FlaskData came together to collaborate on increasing drug safety using data science. This project was initiated by Flaskdata, an Israeli data automation platform that provides robust digital data management and automated monitoring tools enabling tight adherence to clinical protocols for biotech, biopharma, and connected medical devices.

Omdena is a game-changer

From a couple of connections on my LinkedIn network, I came to know about Omdena’s challenges. I was taken by this sentence on Omdena page – ‘The world´s only place for truly collaborative AI projects to apply your skills on real-world data with change-makers from around the world.‘ My initial enthusiasm led me to read up a bunch of interesting blogs on Omdena & Medium about their projects involving data science for good

Omdena is a game-changer in using AI to create social impact and makes a difference in tackling/gaining insights into societal and infrastructural challenges. It was exciting to see how people come together from across the world to work on a challenge and realize an impactful solution. 

This prompted me to apply for the drug safety challenge and was excited to be selected to work on this project. Being a novice in Data Science, it was also inspiring to read about paths and journeys taken by members of the Omdena community from a beginner to being an expert and landing jobs in many different companies.

Detecting anomalies in clinical data

The actual challenge involved detecting anomalies in clinical data for early-stage drug & device projects and building an automated API that works well on high dimensional data being model-free and scales well. The API is the minimum viable product (MVP) to be delivered after two sprints & a timeline of 8 weeks for the entire project. The data had fundamental challenges by way of lack of data before clinical trials, smaller training datasets for certain ailments, high dimensional datasets, bias, noise, lack of reliability, uniqueness within datasets apart from the usual challenges such as feature engineering based on domain expertise, missing data, time stamps, time series drifts & spikes, etc. The datasets explored included breast cancer datasets, migraine paint report datasets, and adverse event/placebo datasets in pancreatic cancer.

The beginning (Week 1 & 2) of this project was a bit overwhelming. I have never worked with so many experts from different backgrounds and skills before. The first couple of weeks were spent reading to get an understanding of the data, technical vocabulary apart from the garbled column names & the data instances. 

Even for people with ‘learn by doing‘ beliefs, it was hard to get started with just an initial look/plot of the data. 

At this crucial juncture, the sense of community via the Slack channel became clear. As per Omdena’s model of collaborative learning, no one is ever assigned a task and the project progresses in a self-driven environment with taking initiatives. 

Collaboration and teamwork

Slowly in week -3, different tasks were delineated, and various experienced members volunteered to be task leaders (TLs).  Figure 1 shows the plan that materialized almost midway into the project. Figure 1(A) shows the workflow for the initial labeling, ETL, and modeling while figure 1(B) shows the design of the API to be constructed at the end of this project. 

Anomaly detection in clinical trial data - Source: Omdena

Figure 1 (A) The rough outline of the different tasks at the beginning of the project (B) An outline for the final deliverable

A great learning process came from codes shared, members trying out different plots/labeling with different data sets, documentation, testing different models, weekly meetings with subject matter experts from Flaskdata, and members sharing a wide variety of reading resources. As a first-timer on Omdena, I joined different tasks & decided to follow the communication between the Task Leads & other members on the Slack channel and was hoping to maximize my learning. Though it was getting difficult to catch up with everything, one of the team members advised me to focus on one area rather than all of it. It was also intriguing to see that task managers did not have all the answers and different members worked on iterative progress towards the final MVP as a team.

Another most important aspect of the project is the weekly status meeting where breakthroughs related to different tasks are presented, ideas that did not work, and the road ahead. Asking for help was never frowned upon and it helped build rapport between members. I was surprised to see posts asking for help and other members sharing ideas & resources for the benefit of all.

How real-time experience is built

In the beginning, the dataset looked incorrigible to an untrained eye especially for people with no prior knowledge of clinical trial data and the data types not conforming to the usual python data types. This truly made the project a relevant real-time experience. The raw data had columns of timestamps, the device from which the data originated, heart rate, glucose levels, etc. The ETL process for this project was different apart from the usual steps of correcting the data types, encoding the categorical variables, removal of columns with 90% missing data, removing highly correlated columns, imputing data, compute interquartile range on numerical data, etc. Iterative imputers with many regressors such as AdaBoost, Stacking, KNN, decisions trees, Bayesian Ridge, and simple imputers were tested on breast cancer data. 

Clinical data and best models

This concluded that the decision tree regressor was the best. The data were in JSON format along with data dictionaries. The anomalies to be classified were separated into a single variable (L1) and multivariate (L2+) anomaly. Unsupervised methods such as DBSCAN (density-based spatial clustering of application with noise, gaussian mixture methods, and decision tree-based isolation forest were explored. Semi-supervised methods with label propagation and KNN were also probed. Interesting additional insight about racial & ethnic bias was also explored.

Anomaly detection - Source: Omdena

Figure 2: Different models probed in this study

DBSCAN is advantageous in separating high and low-density clusters but the epsilon parameter specifying the radius of the neighborhood was not easy for some datasets and the anomaly scores were available. Gaussian mixture models are preferred as their thresholds can be dynamically set but the number of clusters must be decided beforehand, and this is not preferable as the nature of the critical event is not completely defined. In case of a critical/adverse event or an anomaly, the number, nature of change in different variables, and patterns in data are not fully known, and detecting them is difficult. Isolation forests use recursive partitioning that can be represented by tree structures with built-in anomaly scores. The main disadvantage of isolation forest is the way the branching of trees introduces an artifact of rectangular regions (a bias) either in the horizontal or the vertical region after mapping the anomaly scores for all instances in the data[https://en.wikipedia.org/wiki/Isolation_forest|https://ieeexplore.ieee.org/document/8888179]. This is solved by selecting a branch cut with a random slope in an extended isolation forest algorithm. The performance & precision scores turned out to be high and worked well with categorical data and unbalanced data. The final model was chosen after several iterations and several meetings with the staff & subject matter experts of both FlaskData and Omdena team

Deployment and REST API

As a test for minimum functionality and as a first step towards MVP delivery, two sprints spanning over seven consecutive days were implemented. This involved a customer-facing API executing service with data payload and returning a response data with an ‘isAnomaly’ tag to the user in case of an adverse event. Moving to the final MVP required deploying a customer-centric solution in the FlaskData cloud production environment. The REST API was constructed with three different endpoints consisting of missing data anomalies(L1), other anomalies (L2+) along with race & ethnic bias with variables such as investigator, event, subject, country, ethnicity, age group, etc. The future with the designed scalable API looks very promising with customizable endpoints, monitoring & validating models, and integrated active learning across many more datasets and benchmark different models.

Clinical data - Source: Omdena

Figure 3: Customer-oriented API deployed as a final aspect of this project

Conclusion

The final takeaway from my first project with Omdena was that no one knows all the solutions to different challenges but with the combined strength of the team. 

To make the most of the collaborative environment, it is important to communicate openly and ask for help from other team members. 

The beginning of the project may be frustrating as it is an unstructured new team, but it will come together to figure the individual tasks, stage gates, and milestones to the final goal. 

I am grateful to be part of this team that taught me a lot about project management, technical resources, small individual contributions, software literacy, and many more. 

At the beginning of the project, I did not know anything about anomaly detection or isolated forest but with this project and with the support of the team, I was able to understand and adopt this model for smaller projects. 

It was heartening to see a team mostly made of software engineers, data scientists, and budding data enthusiasts from non-biology or non-pharmacology backgrounds build an application to monitor data quality, adverse events, and bias in clinical trials.

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title_css_text_shadow_stylenone
title_css_text_shadow_horizontal_length0em
title_css_text_shadow_vertical_length0em
title_css_text_shadow_blur_strength0em
title_css_text_shadow_colorrgba(0,0,0,0.4)
acf_label_css_text_shadow_stylenone
acf_label_css_text_shadow_horizontal_length0em
acf_label_css_text_shadow_vertical_length0em
acf_label_css_text_shadow_blur_strength0em
acf_label_css_text_shadow_colorrgba(0,0,0,0.4)
label_css_text_shadow_stylenone
label_css_text_shadow_horizontal_length0em
label_css_text_shadow_vertical_length0em
label_css_text_shadow_blur_strength0em
label_css_text_shadow_colorrgba(0,0,0,0.4)
text_before_css_text_shadow_stylenone
text_before_css_text_shadow_horizontal_length0em
text_before_css_text_shadow_vertical_length0em
text_before_css_text_shadow_blur_strength0em
text_before_css_text_shadow_colorrgba(0,0,0,0.4)
seperator_text_shadow_stylenone
seperator_text_shadow_horizontal_length0em
seperator_text_shadow_vertical_length0em
seperator_text_shadow_blur_strength0em
seperator_text_shadow_colorrgba(0,0,0,0.4)
relational_field_item_text_shadow_stylenone
relational_field_item_text_shadow_horizontal_length0em
relational_field_item_text_shadow_vertical_length0em
relational_field_item_text_shadow_blur_strength0em
relational_field_item_text_shadow_colorrgba(0,0,0,0.4)
border_radiion|100%|100%|100%|100%
border_radii_tableton||||
border_radii_phoneon|100%|100%|100%|100%
border_radii_last_editedon|phone
button_text_shadow_stylenone
button_text_shadow_horizontal_length0em
button_text_shadow_vertical_length0em
button_text_shadow_blur_strength0em
button_text_shadow_colorrgba(0,0,0,0.4)
box_shadow_stylenone
box_shadow_colorrgba(0,0,0,0.3)
box_shadow_positionouter
box_shadow_style_buttonnone
box_shadow_color_buttonrgba(0,0,0,0.3)
box_shadow_position_buttonouter
text_shadow_stylenone
text_shadow_horizontal_length0em
text_shadow_vertical_length0em
text_shadow_blur_strength0em
text_shadow_colorrgba(0,0,0,0.4)
disabledoff
global_colors_info{}
V Mukundan

Execution time: 0.0066 seconds

ACF

ID58156
keyfield_623341caec7cf
labelName
nameblog_author_name
prefixacf
typetext
value V Mukundan
parent58155
wrapperArray
_nameblog_author_name
_valid1

Module Settings

custom_identifierACF Item
acf_namefield_623341caec7cf
is_author_acf_fieldoff
post_object_acf_namenone
author_field_typeauthor_post
linked_user_acf_namenone
type_taxonomy_acf_namenone
acf_tagp
show_labeloff
label_seperator:
visibilityon
empty_value_optionhide_module
use_iconoff
icon_color#7EBEC5
use_circleoff
circle_color#7EBEC5
use_circle_borderoff
circle_border_color#7EBEC5
use_icon_font_sizeoff
icon_image_placementleft
image_mobile_stackinginitial
return_formatarray
image_link_urloff
image_link_url_acf_namenone
checkbox_stylearray
checkbox_radio_returnlabel
checkbox_radio_value_typeoff
checkbox_radio_linkoff
link_buttonoff
email_subjectnone
email_body_afternone
add_css_classoff
add_css_loop_layoutoff
add_css_class_selectorbody
link_new_tabon
link_name_acfoff
link_name_acf_namenone
url_link_iconoff
image_sizefull
true_false_conditionoff
true_false_condition_css_selector.et_pb_button
true_false_text_trueTrue
true_false_text_falseFalse
is_audiooff
is_videooff
video_loopon
video_autoplayon
is_oembed_videooff
defer_videooff
defer_video_iconI||divi||400
video_icon_font_sizeoff
pretify_textoff
pretify_seperator,
number_decimal.
show_value_if_zerooff
text_imageoff
is_options_pageoff
is_repeater_loop_layoutoff
linked_post_stylecustom
link_post_seperator,
link_to_post_objecton
loop_layoutnone
columns4
columns_tablet2
columns_mobile1
repeater_dyn_btn_acfnone
text_before_positionsame_line
label_positionsame_line
vertical_alignmentmiddle
admin_labelName
_builder_version4.21.0
_module_presetdefault
title_css_text_alignleft
title_css_font_size14px
title_css_letter_spacing0px
title_css_line_height1em
acf_label_css_text_alignleft
acf_label_css_font_size14px
acf_label_css_letter_spacing0px
acf_label_css_line_height1em
label_css_fontRoboto|700|||||||
label_css_text_alignleft
label_css_letter_spacing0px
text_before_css_font_size14px
text_before_css_letter_spacing0px
text_before_css_line_height1em
seperator_font_size14px
seperator_letter_spacing0px
seperator_line_height1em
relational_field_item_font_size14px
relational_field_item_letter_spacing0px
relational_field_item_line_height1em
background_enable_coloron
use_background_color_gradientoff
background_color_gradient_repeatoff
background_color_gradient_typelinear
background_color_gradient_direction180deg
background_color_gradient_direction_radialcenter
background_color_gradient_stops#2b87da 0%|#29c4a9 100%
background_color_gradient_unit%
background_color_gradient_overlays_imageoff
background_color_gradient_start#2b87da
background_color_gradient_start_position0%
background_color_gradient_end#29c4a9
background_color_gradient_end_position100%
background_enable_imageon
parallaxoff
parallax_methodon
background_sizecover
background_image_widthauto
background_image_heightauto
background_positioncenter
background_horizontal_offset0
background_vertical_offset0
background_repeatno-repeat
background_blendnormal
background_enable_video_mp4on
background_enable_video_webmon
allow_player_pauseoff
background_video_pause_outside_viewporton
background_enable_pattern_styleoff
background_pattern_stylepolka-dots
background_pattern_colorrgba(0,0,0,0.2)
background_pattern_sizeinitial
background_pattern_widthauto
background_pattern_heightauto
background_pattern_repeat_origintop_left
background_pattern_horizontal_offset0
background_pattern_vertical_offset0
background_pattern_repeatrepeat
background_pattern_blend_modenormal
background_enable_mask_styleoff
background_mask_stylelayer-blob
background_mask_color#ffffff
background_mask_aspect_ratiolandscape
background_mask_sizestretch
background_mask_widthauto
background_mask_heightauto
background_mask_positioncenter
background_mask_horizontal_offset0
background_mask_vertical_offset0
background_mask_blend_modenormal
custom_buttonoff
button_text_size20
button_bg_use_color_gradientoff
button_bg_color_gradient_repeatoff
button_bg_color_gradient_typelinear
button_bg_color_gradient_direction180deg
button_bg_color_gradient_direction_radialcenter
button_bg_color_gradient_stops#2b87da 0%|#29c4a9 100%
button_bg_color_gradient_unit%
button_bg_color_gradient_overlays_imageoff
button_bg_color_gradient_start#2b87da
button_bg_color_gradient_start_position0%
button_bg_color_gradient_end#29c4a9
button_bg_color_gradient_end_position100%
button_bg_enable_imageon
button_bg_parallaxoff
button_bg_parallax_methodon
button_bg_sizecover
button_bg_image_widthauto
button_bg_image_heightauto
button_bg_positioncenter
button_bg_horizontal_offset0
button_bg_vertical_offset0
button_bg_repeatno-repeat
button_bg_blendnormal
button_bg_enable_video_mp4on
button_bg_enable_video_webmon
button_bg_allow_player_pauseoff
button_bg_video_pause_outside_viewporton
button_use_iconon
button_icon_placementright
button_on_hoveron
positioningnone
position_origin_atop_left
position_origin_ftop_left
position_origin_rtop_left
text_orientationleft
widthauto
max_widthnone
module_alignmentleft
min_heightauto
heightauto
max_heightnone
custom_margin_tablet||10px||false|false
custom_margin_phone||10px||false|false
custom_margin_last_editedon|tablet
custom_padding5px||||false|false
filter_hue_rotate0deg
filter_saturate100%
filter_brightness100%
filter_contrast100%
filter_invert0%
filter_sepia0%
filter_opacity100%
filter_blur0px
mix_blend_modenormal
animation_stylenone
animation_directioncenter
animation_duration1000ms
animation_delay0ms
animation_intensity_slide50%
animation_intensity_zoom50%
animation_intensity_flip50%
animation_intensity_fold50%
animation_intensity_roll50%
animation_starting_opacity0%
animation_speed_curveease-in-out
animation_repeatonce
hover_transition_duration300ms
hover_transition_delay0ms
hover_transition_speed_curveease
link_option_url_new_windowoff
sticky_positionnone
sticky_offset_top0px
sticky_offset_bottom0px
sticky_limit_topnone
sticky_limit_bottomnone
sticky_offset_surroundingon
sticky_transitionon
motion_trigger_startmiddle
hover_enabled0
title_css_text_align_tabletcenter
title_css_text_align_phonecenter
title_css_text_align_last_editedon|phone
acf_label_css_text_align_tabletcenter
acf_label_css_text_align_phonecenter
acf_label_css_text_align_last_editedon|phone
label_css_text_align_tabletcenter
label_css_text_align_phonecenter
label_css_text_align_last_editedon|desktop
text_orientation_tabletcenter
text_orientation_phonecenter
text_orientation_last_editedon|phone
module_alignment_tabletcenter
module_alignment_phonecenter
module_alignment_last_editedon|desktop
title_css_text_shadow_stylenone
title_css_text_shadow_horizontal_length0em
title_css_text_shadow_vertical_length0em
title_css_text_shadow_blur_strength0em
title_css_text_shadow_colorrgba(0,0,0,0.4)
acf_label_css_text_shadow_stylenone
acf_label_css_text_shadow_horizontal_length0em
acf_label_css_text_shadow_vertical_length0em
acf_label_css_text_shadow_blur_strength0em
acf_label_css_text_shadow_colorrgba(0,0,0,0.4)
label_css_text_shadow_stylenone
label_css_text_shadow_horizontal_length0em
label_css_text_shadow_vertical_length0em
label_css_text_shadow_blur_strength0em
label_css_text_shadow_colorrgba(0,0,0,0.4)
text_before_css_text_shadow_stylenone
text_before_css_text_shadow_horizontal_length0em
text_before_css_text_shadow_vertical_length0em
text_before_css_text_shadow_blur_strength0em
text_before_css_text_shadow_colorrgba(0,0,0,0.4)
seperator_text_shadow_stylenone
seperator_text_shadow_horizontal_length0em
seperator_text_shadow_vertical_length0em
seperator_text_shadow_blur_strength0em
seperator_text_shadow_colorrgba(0,0,0,0.4)
relational_field_item_text_shadow_stylenone
relational_field_item_text_shadow_horizontal_length0em
relational_field_item_text_shadow_vertical_length0em
relational_field_item_text_shadow_blur_strength0em
relational_field_item_text_shadow_colorrgba(0,0,0,0.4)
button_text_shadow_stylenone
button_text_shadow_horizontal_length0em
button_text_shadow_vertical_length0em
button_text_shadow_blur_strength0em
button_text_shadow_colorrgba(0,0,0,0.4)
box_shadow_stylenone
box_shadow_colorrgba(0,0,0,0.3)
box_shadow_positionouter
box_shadow_style_buttonnone
box_shadow_color_buttonrgba(0,0,0,0.3)
box_shadow_position_buttonouter
text_shadow_stylenone
text_shadow_horizontal_length0em
text_shadow_vertical_length0em
text_shadow_blur_strength0em
text_shadow_colorrgba(0,0,0,0.4)
disabledoff
global_colors_info{}

V Mukundan

Execution time: 0.0014 seconds

Execution time: 0.0004 seconds

ACF

ID58158
keyfield_6233420dec7d2
labelLinkedin URL
nameblog_linkedin_url
prefixacf
typeurl
valuehttps://www.linkedin.com/in/vineethamukundan/
menu_order2
parent58155
wrapperArray
_nameblog_linkedin_url
_valid1

Module Settings

custom_identifierLinkedin
acf_namefield_6233420dec7d2
is_author_acf_fieldoff
post_object_acf_namenone
author_field_typeauthor_post
linked_user_acf_namenone
type_taxonomy_acf_namenone
acf_tagspan
show_labeloff
label_seperator:
visibilityon
empty_value_optionhide_module
use_iconon
font_icon||divi||400
icon_color#0d8de2
use_circleoff
circle_color#7EBEC5
use_circle_borderoff
circle_border_color#7EBEC5
use_icon_font_sizeoff
icon_image_placementleft
image_mobile_stackinginitial
return_formaturl
image_link_urloff
image_link_url_acf_namenone
checkbox_stylearray
checkbox_radio_returnlabel
checkbox_radio_value_typeoff
checkbox_radio_linkoff
link_buttonoff
email_subjectnone
email_body_afternone
add_css_classoff
add_css_loop_layoutoff
add_css_class_selectorbody
link_new_tabon
link_name_acfoff
link_name_acf_namenone
url_link_iconon
image_sizefull
true_false_conditionoff
true_false_condition_css_selector.et_pb_button
true_false_text_trueTrue
true_false_text_falseFalse
is_audiooff
is_videooff
video_loopon
video_autoplayon
is_oembed_videooff
defer_videooff
defer_video_iconI||divi||400
video_icon_font_sizeoff
pretify_textoff
pretify_seperator,
number_decimal.
show_value_if_zerooff
text_imageoff
is_options_pageoff
is_repeater_loop_layoutoff
linked_post_stylecustom
link_post_seperator,
link_to_post_objecton
loop_layoutnone
columns4
columns_tablet2
columns_mobile1
repeater_dyn_btn_acfnone
button_alignmentleft
text_before_positionsame_line
label_positionsame_line
vertical_alignmentmiddle
admin_labelLinkedin
module_classlinkedin
_builder_version4.19.5
_module_presetdefault
title_css_text_alignleft
title_css_font_size14px
title_css_letter_spacing0px
title_css_line_height1em
acf_label_css_text_alignleft
acf_label_css_font_size14px
acf_label_css_letter_spacing0px
acf_label_css_line_height1em
label_css_text_alignleft
label_css_letter_spacing0px
text_before_css_font_size14px
text_before_css_letter_spacing0px
text_before_css_line_height1em
seperator_text_alignleft
seperator_font_size14px
seperator_letter_spacing0px
seperator_line_height1em
relational_field_item_text_alignleft
relational_field_item_font_size14px
relational_field_item_letter_spacing0px
relational_field_item_line_height1em
background_enable_coloron
use_background_color_gradientoff
background_color_gradient_repeatoff
background_color_gradient_typelinear
background_color_gradient_direction180deg
background_color_gradient_direction_radialcenter
background_color_gradient_stops#2b87da 0%|#29c4a9 100%
background_color_gradient_unit%
background_color_gradient_overlays_imageoff
background_color_gradient_start#2b87da
background_color_gradient_start_position0%
background_color_gradient_end#29c4a9
background_color_gradient_end_position100%
background_enable_imageon
parallaxoff
parallax_methodon
background_sizecover
background_image_widthauto
background_image_heightauto
background_positioncenter
background_horizontal_offset0
background_vertical_offset0
background_repeatno-repeat
background_blendnormal
background_enable_video_mp4on
background_enable_video_webmon
allow_player_pauseoff
background_video_pause_outside_viewporton
background_enable_pattern_styleoff
background_pattern_stylepolka-dots
background_pattern_colorrgba(0,0,0,0.2)
background_pattern_sizeinitial
background_pattern_widthauto
background_pattern_heightauto
background_pattern_repeat_origintop_left
background_pattern_horizontal_offset0
background_pattern_vertical_offset0
background_pattern_repeatrepeat
background_pattern_blend_modenormal
background_enable_mask_styleoff
background_mask_stylelayer-blob
background_mask_color#ffffff
background_mask_aspect_ratiolandscape
background_mask_sizestretch
background_mask_widthauto
background_mask_heightauto
background_mask_positioncenter
background_mask_horizontal_offset0
background_mask_vertical_offset0
background_mask_blend_modenormal
custom_buttonon
button_text_size14px
button_bg_use_color_gradientoff
button_bg_color_gradient_repeatoff
button_bg_color_gradient_typelinear
button_bg_color_gradient_direction180deg
button_bg_color_gradient_direction_radialcenter
button_bg_color_gradient_stops#2b87da 0%|#29c4a9 100%
button_bg_color_gradient_unit%
button_bg_color_gradient_overlays_imageoff
button_bg_color_gradient_start#2b87da
button_bg_color_gradient_start_position0%
button_bg_color_gradient_end#29c4a9
button_bg_color_gradient_end_position100%
button_bg_enable_imageon
button_bg_parallaxoff
button_bg_parallax_methodon
button_bg_sizecover
button_bg_image_widthauto
button_bg_image_heightauto
button_bg_positioncenter
button_bg_horizontal_offset0
button_bg_vertical_offset0
button_bg_repeatno-repeat
button_bg_blendnormal
button_bg_enable_video_mp4on
button_bg_enable_video_webmon
button_bg_allow_player_pauseoff
button_bg_video_pause_outside_viewporton
button_border_width0px
button_use_iconoff
button_icon_placementright
button_on_hoveron
button_custom_padding0px|0px|0px|0px|true|true
positioningnone
position_origin_atop_left
position_origin_ftop_left
position_origin_rtop_left
text_orientationleft
widthauto
max_widthnone
module_alignmentleft
min_heightauto
heightauto
max_heightnone
custom_margin_tablet||10px||false|false
custom_margin_phone||10px||false|false
custom_margin_last_editedon|tablet
filter_hue_rotate0deg
filter_saturate100%
filter_brightness100%
filter_contrast100%
filter_invert0%
filter_sepia0%
filter_opacity100%
filter_blur0px
mix_blend_modenormal
animation_stylenone
animation_directioncenter
animation_duration1000ms
animation_delay0ms
animation_intensity_slide50%
animation_intensity_zoom50%
animation_intensity_flip50%
animation_intensity_fold50%
animation_intensity_roll50%
animation_starting_opacity0%
animation_speed_curveease-in-out
animation_repeatonce
hover_transition_duration300ms
hover_transition_delay0ms
hover_transition_speed_curveease
link_option_url_new_windowoff
sticky_positionnone
sticky_offset_top0px
sticky_offset_bottom0px
sticky_limit_topnone
sticky_limit_bottomnone
sticky_offset_surroundingon
sticky_transitionon
motion_trigger_startmiddle
hover_enabled0
title_css_text_align_tabletcenter
title_css_text_align_phonecenter
title_css_text_align_last_editedon|phone
acf_label_css_text_align_tabletcenter
acf_label_css_text_align_phonecenter
acf_label_css_text_align_last_editedon|tablet
label_css_text_align_tabletcenter
label_css_text_align_phonecenter
label_css_text_align_last_editedon|desktop
relational_field_item_text_align_tabletcenter
relational_field_item_text_align_phonecenter
relational_field_item_text_align_last_editedon|tablet
text_orientation_tabletcenter
text_orientation_phonecenter
text_orientation_last_editedon|phone
module_alignment_tabletcenter
module_alignment_phonecenter
module_alignment_last_editedon|desktop
custom_css_main_elementdisplay:block;
title_css_text_shadow_stylenone
title_css_text_shadow_horizontal_length0em
title_css_text_shadow_vertical_length0em
title_css_text_shadow_blur_strength0em
title_css_text_shadow_colorrgba(0,0,0,0.4)
acf_label_css_text_shadow_stylenone
acf_label_css_text_shadow_horizontal_length0em
acf_label_css_text_shadow_vertical_length0em
acf_label_css_text_shadow_blur_strength0em
acf_label_css_text_shadow_colorrgba(0,0,0,0.4)
label_css_text_shadow_stylenone
label_css_text_shadow_horizontal_length0em
label_css_text_shadow_vertical_length0em
label_css_text_shadow_blur_strength0em
label_css_text_shadow_colorrgba(0,0,0,0.4)
text_before_css_text_shadow_stylenone
text_before_css_text_shadow_horizontal_length0em
text_before_css_text_shadow_vertical_length0em
text_before_css_text_shadow_blur_strength0em
text_before_css_text_shadow_colorrgba(0,0,0,0.4)
seperator_text_shadow_stylenone
seperator_text_shadow_horizontal_length0em
seperator_text_shadow_vertical_length0em
seperator_text_shadow_blur_strength0em
seperator_text_shadow_colorrgba(0,0,0,0.4)
relational_field_item_text_shadow_stylenone
relational_field_item_text_shadow_horizontal_length0em
relational_field_item_text_shadow_vertical_length0em
relational_field_item_text_shadow_blur_strength0em
relational_field_item_text_shadow_colorrgba(0,0,0,0.4)
button_text_shadow_stylenone
button_text_shadow_horizontal_length0em
button_text_shadow_vertical_length0em
button_text_shadow_blur_strength0em
button_text_shadow_colorrgba(0,0,0,0.4)
box_shadow_stylenone
box_shadow_colorrgba(0,0,0,0.3)
box_shadow_positionouter
box_shadow_style_buttonnone
box_shadow_color_buttonrgba(0,0,0,0.3)
box_shadow_position_buttonouter
text_shadow_stylenone
text_shadow_horizontal_length0em
text_shadow_vertical_length0em
text_shadow_blur_strength0em
text_shadow_colorrgba(0,0,0,0.4)
disabledoff
global_colors_info{}
custom_css_main_element_last_editedon|phone
custom_css_main_element_tabletdisplay:block;
custom_css_main_element_phonedisplay:block;

Execution time: 0.0017 seconds

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5 Comments
  1. ClinicalResearch

    Hey thanks for sharing this blog over here. It seems useful to start career in clinical research. We will look forward for more updates.

    Reply
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